Mitochondrial diseases are very complex disorders that until a few years ago were little known by the scientific community itself. In recent years, giant steps have been taken in the study of the basic mechanisms involved in these diseases, confirmed by the passage of the main focus of research from the study of the possibilities of making a diagnosis to the identification and development of therapeutic strategies and clinical trials.

The process of converting food and oxygen into energy requires hundreds of chemical reactions, and each chemical reaction must run almost perfectly in order to have a continuous supply of energy. When one or more components of these chemical reactions do not run perfectly, there is an energy crisis, and the cells cannot function normally. As a result, the incompletely burned food might accumulate as a toxin inside the body. This is called Auto-toxin. In Ayurveda, this is called Ama Dosha. These auto-toxins can stop other chemical reactions that are important for the cells to survive, making the energy crisis even worse. In addition, these auto-toxins can act as free radicals (reactive substances that readily form harmful compounds with other molecules) that can damage the mitochondria over time, causing mitochondrial disorders. Mitochondrial diseases might affect functions of the brain, nerves (including the nerves to the stomach and intestines), muscles, kidneys, heart, liver, eyes, ears, or pancreas. Depending on how severe the mitochondrial disorder is, the illness can range in severity from mild to fatal.

Ayurveda can help reduce symptoms or delay the progression of the disease. Ayurvedic treatment with Rasayana molecules is medicinally important. Curcumin, Withanaloids, Boswellic acid, and Fulvic acid are efficient to stop further deterioration of muscles due to several genetic NMD, including mitochondrial diseases. These molecules are basically anti-oxidants, blocks nuclear k-factor, and will help delay the muscle degeneration. Medicines improve muscle strength and functional abilities. Ayurvedic Rasayana medicines do not alter the patient’s genetic code or introduce genetic materials into the body. These safe and natural medicines are developed and being clinically used by AMDS India for Care through Ayurveda research project since 1995.

AMDS India utilizes a holistic multi-modal treatment approach. The patients are examined according to both, Ayurvedic and Western medical methods. The results of these examinations help to design the individual’s clinical programs. The Ayush Samiti, the parent body of AMDS India, plans for long term follow-up studies on Mito human patients. AMDS India currently verifying the efficiency of Prana Drops in Mito children. The focus is on the inhibitory effect on the incorporation of the ribosome -35S into the granulation tissue and the uncoupling effect on oxidative phosphorylation in the mitochondria of granulation tissue.

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